Shafioul, Azam Sharif Mohammed Pyo, Jung In Kim, Kwan Soo Cheong, Chan Seong 2024-01-20T13:31:22Z 2024-01-20T13:31:22Z 2021-09-05 2012-12 1381-1177 https://pubs.kist.re.kr/handle/201004/128585 Natural R-(-)-xanthorrhizol possess a number of therapeutic activities including anti-cancer. The pharmacokinetic properties of that poorly aqueous soluble compound could be improved by incorporating it into polymeric materials. Glycerol can produce a functionalized polymer through a polycondensation process. Enzymatic polycondensation of glycerol and divinylesters was studied and xanthorrhizol was covalently loaded via a butanedioate linker to the polymer backbone. It was observed that xanthorrhizol loading to the polymer backbone increases with the increasing of the chain length of a dioate moiety. Enzyme-mediated xanthorrhizol release from a polymer backbone shows that the polymeric prodrug is able to release xanthorrhizol in a sustained manner. Therefore, the approach described here might be valuable for controlled loading and release of such phenolic sesquiterpenes from the polymeric prodrug. (C) 2012 Elsevier B.V. All rights reserved. English ELSEVIER CURCUMA-XANTHORRHIZA DIVINYL SEBACATE POLYESTERS POLYMERIZATION DELIVERY Synthesis of poly (glycerol-co-dioate-co-butanedioate-co-xanthorrhizol) ester and a study of chain length effect on pendant group loading Article 10.1016/j.molcatb.2012.05.022 1 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v.84, pp.198 - 204 JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC 84 198 204 scie scopus 000309573100033 2-s2.0-84866347250 Biochemistry & Molecular Biology Chemistry, Physical Biochemistry & Molecular Biology Chemistry Article; Proceedings Paper CURCUMA-XANTHORRHIZA DIVINYL SEBACATE POLYESTERS POLYMERIZATION DELIVERY Enzyme Polycondensation Pendant group loading Drug delivery system Xanthorrhizol