Jee, Jun-Pil Na, Jin Hee Lee, Sangmin Kim, Sun Hwa Choi, Kuiwon Yeo, Yoon Kwon, Ick Chan 2024-01-20T13:31:41Z 2024-01-20T13:31:41Z 2021-09-05 2012-12 1359-0286 https://pubs.kist.re.kr/handle/201004/128601 Nanomedicine has recently emerged as an efficient way of overcoming various limitations of conventional medicine, such as a lack of selectivity, poor pharmacokinetics and undesirable side effects. Especially, nanoparticles (NPs) technology has attracted more attentions in nanomedicine based approaches for cancer therapy due to unique physicochemical properties. Although NPs have been intensively studied for tumor targeting and showed some promising results, there is still limited understanding about pharmacokinetic (PK) and pharmacodynamic (PD) properties and tumor targeting efficiency of NPs. Thus, advances in understanding of these issues in NPs technology can create more opportunities to translate nanomedicine approaches into improved clinical outcomes. The goal of this review is to understand the key factors that are required for tumor targeted delivery of NPs. In addition, the review article more specifically describes important considerations in the formulation of chitosan nanoparticles such as particle size, shape, stiffness and deformability. (C) 2013 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD SELF-ASSEMBLED NANOPARTICLES DRUG-DELIVERY SYSTEMS TUMOR-BEARING MICE POLYMERIC NANOPARTICLES ANTITUMOR EFFICACY DNA NANOPARTICLES MOLECULAR-WEIGHT THERAPY CARRIERS ACCUMULATION Cancer targeting strategies in nanomedicine: Design and application of chitosan nanoparticles Article 10.1016/j.cossms.2013.01.002 1 CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, v.16, no.6, pp.333 - 342 CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE 16 6 333 342 scie scopus 000317639300008 2-s2.0-84875241723 Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Materials Science Physics Review SELF-ASSEMBLED NANOPARTICLES DRUG-DELIVERY SYSTEMS TUMOR-BEARING MICE POLYMERIC NANOPARTICLES ANTITUMOR EFFICACY DNA NANOPARTICLES MOLECULAR-WEIGHT THERAPY CARRIERS ACCUMULATION Cancer targeting Nanomedicine Chitosan nanoparticle Targeted drug delivery