Sun, Bo Yeo, Yoon 2024-01-20T13:31:53Z 2024-01-20T13:31:53Z 2021-09-05 2012-12 1359-0286 https://pubs.kist.re.kr/handle/201004/128611 Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products. (C) 2012 Elsevier Ltd. All rights reserved. English PERGAMON-ELSEVIER SCIENCE LTD PHASE-I TRIAL TISSUE DISTRIBUTION INTRAPERITONEAL DOCETAXEL ORIDONIN NANOSUSPENSION ANTITUMOR EFFICACY EUDRAGIT RS100(R) TOP-DOWN FORMULATION PHARMACOKINETICS PERITONEAL Nanocrystals for the parenteral delivery of poorly water-soluble drugs Article 10.1016/j.cossms.2012.10.004 1 CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, v.16, no.6, pp.295 - 301 CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE 16 6 295 301 scie scopus 000317639300004 2-s2.0-84875242104 Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Materials Science Physics Review PHASE-I TRIAL TISSUE DISTRIBUTION INTRAPERITONEAL DOCETAXEL ORIDONIN NANOSUSPENSION ANTITUMOR EFFICACY EUDRAGIT RS100(R) TOP-DOWN FORMULATION PHARMACOKINETICS PERITONEAL Nanocrystals Nanosuspension Parenteral applications Poorly water-soluble drugs