Cho, Yoon Shin Lee, Jong-Young Park, Kyong Soo Nho, Chu Won 2024-01-20T13:31:55Z 2024-01-20T13:31:55Z 2021-09-05 2012-12 1534-4827 https://pubs.kist.re.kr/handle/201004/128613 Because type 2 diabetes (T2D) is highly familial, there has been a concentrated effort to uncover the genetic basis of T2D worldwide over the last decade. In East Asians, T2D is experiencing a rapidly rising prevalence that is characterized by a relatively lower body mass index, as compared with that in Europeans. To date, at least 15 convincing T2D loci have been identified from large-scale genome-wide association studies and meta-analyses in East Asians. Many of these are likely responsible for pancreatic beta cell function, as indicated in studies from Europeans. Many T2D loci have been replicated across the ethnic groups. There are, however, substantial interethnic differences in frequency and effect size of these risk alleles. Despite accumulating genetic information on T2D, there are still limitations in our ability to explain the rapidly rising prevalence and lean phenotype of disease observed in East Asians, suggesting that more extensive work using diverse research strategies is needed in the future. English CURRENT MEDICINE GROUP GENOME-WIDE ASSOCIATION PROTEIN-TYROSINE-PHOSPHATASE IONOTROPIC GLUTAMATE RECEPTORS UBIQUITIN-PROTEASOME SYSTEM LARGE-SCALE ASSOCIATION SUSCEPTIBILITY LOCI TCF7L2 POLYMORPHISMS GLUCOSE-HOMEOSTASIS FASTING GLUCOSE COMMON VARIANTS Genetics of Type 2 Diabetes in East Asian Populations Article 10.1007/s11892-012-0326-z 1 CURRENT DIABETES REPORTS, v.12, no.6, pp.686 - 696 CURRENT DIABETES REPORTS 12 6 686 696 scie scopus 000310706500007 2-s2.0-84870702024 Endocrinology & Metabolism Endocrinology & Metabolism Article GENOME-WIDE ASSOCIATION PROTEIN-TYROSINE-PHOSPHATASE IONOTROPIC GLUTAMATE RECEPTORS UBIQUITIN-PROTEASOME SYSTEM LARGE-SCALE ASSOCIATION SUSCEPTIBILITY LOCI TCF7L2 POLYMORPHISMS GLUCOSE-HOMEOSTASIS FASTING GLUCOSE COMMON VARIANTS Type 2 diabetes Genome-wide association (GWA) study Meta-analysis Disease susceptibility locus HapMap Genetic variant Ethnic populations Genetics