Doh, K.-O. Yeo, Y. 2024-01-20T13:32:27Z 2024-01-20T13:32:27Z 2021-08-31 2012-12 2041-5990 https://pubs.kist.re.kr/handle/201004/128637 Polysaccharides have been used in various biomedical applications due to availability and biocompatibility. In particular, polysaccharides have gained increasing interest in the development of functional nanomedicines as a component to provide a stealth function, improve interactions with target tissues or enable environment-responsive drug release. This review discusses recent advances in nanomedicine engineering based on polysaccharides with a specific emphasis on the rationale, applications and the remaining challenges. ？ 2012 Future Science Ltd. English chitosan chondroitin sulfate dextran doxorubicin heparin hyaluronic acid hydrophilic glycol chitosan low molecular weight chitosan nanoparticle poly(alkylacyanoacrylate) nanoparticle polyethyleneimine polyglactin polysaccharide small interfering RNA unclassified drug bioaccumulation cell interaction cell transport chemical modification complex formation conjugation drug conformation drug delivery system drug dosage form comparison endocytosis gene silencing genetic transfection human material coating molecular dynamics molecular weight nanomedicine nonhuman particle size priority journal review structure activity relation surface modification Chitosan Chondroitin Sulfates Heparin Humans Hyaluronic Acid Nanomedicine Nanoparticles Polysaccharides Surface Properties Application of polysaccharides for surface modification of nanomedicines Article 10.4155/tde.12.105 1 Therapeutic Delivery, v.3, no.12, pp.1447 - 1456 Therapeutic Delivery 3 12 1447 1456 scopus 2-s2.0-84870720550 Review chitosan chondroitin sulfate dextran doxorubicin heparin hyaluronic acid hydrophilic glycol chitosan low molecular weight chitosan nanoparticle poly(alkylacyanoacrylate) nanoparticle polyethyleneimine polyglactin polysaccharide small interfering RNA unclassified drug bioaccumulation cell interaction cell transport chemical modification complex formation conjugation drug conformation drug delivery system drug dosage form comparison endocytosis gene silencing genetic transfection human material coating molecular dynamics molecular weight nanomedicine nonhuman particle size priority journal review structure activity relation surface modification Chitosan Chondroitin Sulfates Heparin Humans Hyaluronic Acid Nanomedicine Nanoparticles Polysaccharides Surface Properties