Cho, Hye Jung El-Gamal, Mohammed I. Oh, Chang-Hyun Lee, So Ha Kim, Garam Hong, Jun Hee Choi, Hong Seok Yoo, Kyung Ho 2024-01-20T13:32:37Z 2024-01-20T13:32:37Z 2021-09-05 2012-11-20 0253-2964 https://pubs.kist.re.kr/handle/201004/128644 A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with IC50 value of 0.41 mu M. English WILEY-V C H VERLAG GMBH DESIGN DIARYLAMIDES DIARYLUREAS DIAGNOSIS Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line Article 10.5012/bkcs.2012.33.11.3635 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.11, pp.3635 - 3639 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 33 11 3635 3639 scie scopus kci ART001711840 000311816000020 2-s2.0-84870026320 Chemistry, Multidisciplinary Chemistry Article DESIGN DIARYLAMIDES DIARYLUREAS DIAGNOSIS A375P Aminoisoquinoline Anticancer Diarylurea Melanoma