Kang, Kyungsu Lee, Kyung-Mi Yoo, Ji-Hye Lee, Hee Ju Kim, Chul Young Nho, Chu Won 2024-01-20T13:32:40Z 2024-01-20T13:32:40Z 2021-09-04 2012-11-16 0006-291X https://pubs.kist.re.kr/handle/201004/128647 Here, we report that gomisin J and gomisin N. clibenzocyclooctadiene type lignans isolated from Sch (sonchinensis, inhibit Wnt/beta-catenin signaling in HCT116 cells. Gomisins J and N appear to inhibit Wnt/Bcatenin signaling by disrupting the interaction between beta-catenin and its specific target DNA sequences (TCF binding elements, TBE) rather than by altering the expression of the beta-catenin protein. Gomisins J and N inhibit HCT116 cell proliferation by arresting the cell cycle at the G0/G1 phase. The G0/G1 phase arrest induced by gomisins J and N appears to be caused by a decrease in the expression of Cyclin D1, a representative target gene of the Wnt/beta-catenin signaling pathway, as well as Cdk2, Cdk4, and E2F-1. Therefore, gomisins J and N, the novel Wnt/beta-catenin inhibitors discovered in this study, may serve as potential agents for the prevention and treatment of human colorectal cancers. (C) 2012 Elsevier Inc. All rights reserved. English ACADEMIC PRESS INC ELSEVIER SCIENCE COLON-CANCER CELLS SCHISANDRA-CHINENSIS BETA-CATENIN SUPPRESSES GROWTH ACTIVATION COMPONENTS APOPTOSIS Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/beta-catenin signaling pathway in HCT116 cells Article 10.1016/j.bbrc.2012.10.046 1 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.428, no.2, pp.285 - 291 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 428 2 285 291 scie scopus 000312431900014 2-s2.0-84869204968 Biochemistry & Molecular Biology Biophysics Biochemistry & Molecular Biology Biophysics Article COLON-CANCER CELLS SCHISANDRA-CHINENSIS BETA-CATENIN SUPPRESSES GROWTH ACTIVATION COMPONENTS APOPTOSIS Wnt/beta-catenin Cancer chemoprevention Dibenzocyclooctadiene lignan Schisandra chinensis Gomisin Cyclin D1