Yoon, Bo-Eun Woo, Junsung Lee, C. Justin 2024-01-20T13:34:14Z 2024-01-20T13:34:14Z 2021-09-04 2012-11 0364-3190 https://pubs.kist.re.kr/handle/201004/128727 GABA (gamma-aminobutyric acid) is considered to be the major inhibitory neurotransmitter that is synthesized in and released from GABA-ergic neurons in the brain. However, recent studies have shown that not only neurons but astrocytes contain a considerable amount of GABA, which can be released and activate the receptors responsive to GABA. In addition, astrocytes are themselves responsive to GABA by expressing GABA receptors. These exciting new findings raise more questions about the origin of GABA, whether it is synthesized or taken up, and about the role of astrocytic GABA and GABA receptors. In this review, we propose several potential pathways for astrocytes to accumulate GABA and discuss the evidence for functional expression of GABA receptors in astrocytes. English SPRINGER/PLENUM PUBLISHERS GAMMA-AMINOBUTYRIC-ACID GLIAL-CELLS CULTURED ASTROCYTES SYNAPTIC-TRANSMISSION CA2+ TRANSIENTS NERVOUS-SYSTEM BERGMANN GLIA SPINAL-CORD IN-SITU EXPRESSION Astrocytes as GABA-ergic and GABA-ceptive Cells Article 10.1007/s11064-012-0808-z 1 NEUROCHEMICAL RESEARCH, v.37, no.11, pp.2474 - 2479 NEUROCHEMICAL RESEARCH 37 11 2474 2479 scie scopus 000310640200017 2-s2.0-84871439428 Biochemistry & Molecular Biology Neurosciences Biochemistry & Molecular Biology Neurosciences & Neurology Article GAMMA-AMINOBUTYRIC-ACID GLIAL-CELLS CULTURED ASTROCYTES SYNAPTIC-TRANSMISSION CA2+ TRANSIENTS NERVOUS-SYSTEM BERGMANN GLIA SPINAL-CORD IN-SITU EXPRESSION Astrocyte Glial GABA Tonic inhibition