Park, Soon-Hye Song, Jae-Hyoung Kim, Taejung Shin, Woon-Seob Park, Gab Man Lee, Seokjoon Kim, Young-Joo Choi, Pilju Kim, Heejin Kim, Hui-Seong Kwon, Dur-Han Choi, Hwa Jung Ham, Jungyeob 2024-01-20T14:01:35Z 2024-01-20T14:01:35Z 2021-09-04 2012-10 1660-3397 https://pubs.kist.re.kr/handle/201004/128842 An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC50) of 2.50 mu g/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC50 of 7.11 mu g/mL, and anti-HRV3 activity, with an IC50 of 4.69 mu g/mL, without demonstrable cytotoxicity at a concentration of 20 mu g/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus. English MDPI BROMOPHENOLS Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata Article 10.3390/md10102222 1 MARINE DRUGS, v.10, no.10, pp.2222 - 2233 MARINE DRUGS 10 10 2222 2233 scie scopus 000310453600006 2-s2.0-84868255243 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article BROMOPHENOLS Neorhodomela aculeate red alga polybromocatechol compounds antiviral activity human rhinovirus