Kim, Sangwoo Matyas, Ferenc Lee, Sukchan Acsady, Laszlo Shin, Hee-Sup 2024-01-20T14:02:05Z 2024-01-20T14:02:05Z 2021-09-05 2012-09-18 0027-8424 https://pubs.kist.re.kr/handle/201004/128866 Major cognitive and emotional faculties are dominantly lateralized in the human cerebral cortex. The mechanism of this lateralization has remained elusive owing to the inaccessibility of human brains to many experimental manipulations. In this study we demonstrate the hemispheric lateralization of observational fear learning in mice. Using unilateral inactivation as well as electrical stimulation of the anterior cingulate cortex (ACC), we show that observational fear learning is controlled by the right but not the left ACC. In contrast to the cortex, inactivation of either left or right thalamic nuclei, both of which are in reciprocal connection to ACC, induced similar impairment of this behavior. The data suggest that lateralization of negative emotions is an evolutionarily conserved trait and mainly involves cortical operations. Lateralization of the observational fear learning behavior in a rodentmodelwill allow detailed analysis of cortical asymmetry in cognitive functions. English NATL ACAD SCIENCES SUBTHALAMIC NUCLEUS PREFRONTAL CORTEX STIMULATION BRAIN RATS AMYGDALA EMOTION SYSTEMS PAIN PROJECTIONS Lateralization of observational fear learning at the cortical but not thalamic level in mice Article 10.1073/pnas.1213903109 1 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.38, pp.15497 - 15501 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 109 38 15497 15501 scie scopus 000309211000084 2-s2.0-84866530723 Multidisciplinary Sciences Science & Technology - Other Topics Article SUBTHALAMIC NUCLEUS PREFRONTAL CORTEX STIMULATION BRAIN RATS AMYGDALA EMOTION SYSTEMS PAIN PROJECTIONS social fear anterograde and retrograde tracing