Yuk, Soon H. Oh, Keun Sang Park, Jinah Lee, Eun H. Kim, Kwangmeyung Kwon, Ick C. 2024-01-20T14:02:28Z 2024-01-20T14:02:28Z 2022-01-25 2012-09 0883-9115 https://pubs.kist.re.kr/handle/201004/128886 Docetaxel-loaded composite nanoparticles were prepared by temperature-induced phase transition of a mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing docetaxel. Liquid soybean oil/Tween 80 was used as a solubilizer for docetaxel and Pluronic F-68 to stabilize the liquid soybean oil/Tween 80 containing docetaxel. The phase transition was performed at low temperature to avoid degradation. The docetaxel composite nanoparticles were injected into the tail veins of tumor-bearing mice to evaluate the composite delivery system for the release pattern and the tumor growth. The tumor-targeting capability of composite nanoparticles was verified by noninvasive live animal imaging for the time-dependent excretion profile, the in vivo biodistribution, and the circulation time. English SAGE PUBLICATIONS LTD Docetaxel-loaded composite nanoparticles formed by a temperature-induced phase transition for cancer therapy Article 10.1177/0883911512448752 1 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, v.27, no.5, pp.441 - 452 JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 27 5 441 452 N scie scopus 000308878400003 2-s2.0-84866365760 Biotechnology & Applied Microbiology Materials Science, Biomaterials Polymer Science Biotechnology & Applied Microbiology Materials Science Polymer Science Article VASCULAR-PERMEABILITY PACLITAXEL DELIVERY BEHAVIOR Composite nanoparticles docetaxel in vivo biodistribution Tween 80/soybean oil antitumor efficacy cancer therapy