Yoshimoto, Yukihiro Hasebe, Terumitsu Nagashima, So Kamijo, Aki Nakatani, Tatsuyuki Yamagami, Takuji Kitamura, Noriko Kitagawa, Tomoya Hotta, Atsushi Takahashi, Koki Suzuki, Tetsuya 2024-01-20T14:02:36Z 2024-01-20T14:02:36Z 2022-01-10 2012-09 0021-4922 https://pubs.kist.re.kr/handle/201004/128893 A major clinical concern in coronary intervention for cardiovascular disease is late stent thrombosis after the implantation of drug eluting stents (DES). DES widely used in clinical settings currently utilize polymer coatings, which can induce persistent arterial wall inflammation and delayed vascular healing, resulting in impaired endothelialization. We examined the viability of human umbilical vein endothelial cells (HUVECs) for fluorine-incorporated amorphous carbon (a-C:H:F) coatings, which are known to be anti-thrombogenic. a-C:H:F and a-C:H were synthesized on the tissue culture dishes using radio frequency plasma enhanced chemical vapor deposition by varying the ratio of hexafluoroethane and acetylene. HUVECs were seeded on coated dishes for 6 days. The results indicate that the a-C:H:F surface does not disturb HUVEC proliferation in 6 days of culture and is promising for stent materials that allows the preservation of endothelialization, even if the fluorine concentration of a-C:H surface affects the early adhesion of endothelial cells. (C) 2012 The Japan Society of Applied Physics English JAPAN SOC APPLIED PHYSICS DIAMOND-LIKE CARBON DLC THIN-FILMS PROTEIN ADSORPTION ELUTING STENTS BIOCOMPATIBILITY COATINGS SI IMPLANTATION WETTABILITY ADHESION Human Umbilical Vein Endothelial Cell Interaction with Fluorine-Incorporated Amorphous Carbon Films Article 10.1143/JJAP.51.090129 1 JAPANESE JOURNAL OF APPLIED PHYSICS, v.51, no.9 JAPANESE JOURNAL OF APPLIED PHYSICS 51 9 scie scopus 000308489700029 2-s2.0-84865835770 Physics, Applied Physics Article DIAMOND-LIKE CARBON DLC THIN-FILMS PROTEIN ADSORPTION ELUTING STENTS BIOCOMPATIBILITY COATINGS SI IMPLANTATION WETTABILITY ADHESION