Han, Myung Woul Cho, Kyung-Ja Roh, Jong-Lyel Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon 2024-01-20T14:02:54Z 2024-01-20T14:02:54Z 2021-09-05 2012-09 0022-4790 https://pubs.kist.re.kr/handle/201004/128909 Background and Objectives Little is known about lymph node metastasis and the extent of neck dissection (ND) in patients with submandibular gland (SMG) carcinoma. We therefore evaluated the metastatic topography of neck lymph nodes in patients with SMG carcinoma and the influence of metastases on tumor recurrence and patient survival. Methods The pattern of lymph node spread was analyzed in 64 patients with SMG carcinoma treated from January 1994 to January 2009. Disease-free survival (DFS), overall survival (OS), and distant metastasis-free survival (DMFS) were calculated, and the clinicopathological factors associated with each were analyzed. Results Positive pathological lymph nodes were detected in 31 (48.4%) patients and was found to correlate significantly with histologic grade (P?<?0.001) on univariate analysis. Eight patients (19.5%) had occult cervical metastases. The 5-year DFS, OS, and DMFS rates were 46.8, 56.2, and 58.5%, respectively, and 23 patients (35.9%) experienced systemic failure. Multivariate analyses revealed that T-classification (P?=?0.043) and N-classification (P?=?0.006) were significantly independent predictors of DFS, whereas only N-classification (P?=?0.049) was significantly associated with DMFS. Conclusions Elective ND should be recommended for preoperatively suspected high-grade malignancy in SMG carcinoma. Patients with nodal metastasis should receive more effective therapy to hinder recurrence and distant metastasis. J. Surg. Oncol. 2012; 106:475480. (c) 2012 Wiley Periodicals, Inc. English WILEY NEEDLE-ASPIRATION-CYTOLOGY PRIMARY PAROTID CARCINOMA ELECTIVE NECK DISSECTION GUIDED CORE BIOPSY SALIVARY-GLAND PROGNOSTIC-FACTORS TUMORS CANCER MANAGEMENT DIAGNOSIS Patterns of lymph node metastasis and their influence on outcomes in patients with submandibular gland carcinoma Article 10.1002/jso.23100 1 JOURNAL OF SURGICAL ONCOLOGY, v.106, no.4, pp.475 - 480 JOURNAL OF SURGICAL ONCOLOGY 106 4 475 480 scie scopus 000307550900020 2-s2.0-84865134668 Oncology Surgery Oncology Surgery Article NEEDLE-ASPIRATION-CYTOLOGY PRIMARY PAROTID CARCINOMA ELECTIVE NECK DISSECTION GUIDED CORE BIOPSY SALIVARY-GLAND PROGNOSTIC-FACTORS TUMORS CANCER MANAGEMENT DIAGNOSIS submandibular gland carcinomas prognosis lymph node spread neck dissection