Jin, Jang Mi Choi, Suhee Kim, Young Hwan Choi, Man Ho Kim, Jongwon Kim, Sunghwan 2024-01-20T14:03:10Z 2024-01-20T14:03:10Z 2021-09-05 2012-09 1044-0305 https://pubs.kist.re.kr/handle/201004/128923 The structural effect of a nanoporous gold (NPG) surface on the signal intensities of laser desorption ionization-mass spectrometry (LDI-MS) were investigated using NPG surfaces with controlled structures. The relationship between surface area and LDI efficiency was compared and evaluated. Comparisons between bare flat gold and NPG surfaces show that nano-structures increased LDI efficiency. We also found that the LDI signal decreased with increasing depth of nanoporous layers, thus increasing the surface area. This result agrees with a previous report (Shin J. A. et al., J. Am. Soc. Mass Spectrom. 2010, 21, 989) in which the LDI efficiency of small molecules decreased for ZnO wires with longer lengths. This observation was explained by the penetration and deposition of samples into locations inaccessible to photons because of structural screening. The LDI-MS analysis of oils with NPG surfaces (but without matrix) showed the same trend whereby the NPG with about a 200 nm depth of porous area showed the highest sensitivity. This study clearly shows that the active surface area for solution chemistry can differ from LDI-MS and that NPGs can function as a substrate for LDI oil analysis. English SPRINGER DESORPTION/IONIZATION MASS-SPECTROMETRY NANOPARTICLES SILICON Evaluation of Nanoporous Gold with Controlled Surface Structures for Laser Desorption Ionization (LDI) Analysis: Surface Area Versus LDI Signal Intensity Article 10.1007/s13361-012-0439-2 1 JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, v.23, no.9, pp.1450 - 1453 JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 23 9 1450 1453 scie scopus 000309239400002 2-s2.0-84865711300 Biochemical Research Methods Chemistry, Analytical Chemistry, Physical Spectroscopy Biochemistry & Molecular Biology Chemistry Spectroscopy Article DESORPTION/IONIZATION MASS-SPECTROMETRY NANOPARTICLES SILICON Mass spectrometry Nanoporous gold Laser desorption ionization Petroleum Surface area