Lim, Chang-Keun Shin, Jiyoung Lee, Yong-Deok Kim, Jungahn Oh, Keun Sang Yuk, Soon Hong Jeong, Seo Young Kwon, Ick Chan Kim, Sehoon 2024-01-20T14:03:42Z 2024-01-20T14:03:42Z 2021-09-04 2012-09 1838-7640 https://pubs.kist.re.kr/handle/201004/128952 Phthalocyanine-aggregated Pluronic nanoparticles were constructed as a novel type of near-infrared (NIR) absorber for photothermal therapy. Tiny nanoparticles (similar to 60 nm, FPc NPs) were prepared by aqueous dispersion of phthalocyanine-aggregated self-assembled nanodomains that were phase-separated from the melt mixture with Pluronic. Under NIR laser irradiation, FPc NPs manifested robust heat generation capability, superior to an individual cyanine dye and cyanine-aggregated nanoparticles. Micro-and macroscopic imaging experiments showed that FPc NPs are capable of internalization into live cancer cells as well as tumor accumulation when intravenously administered into living mice. It is shown here that continuous NIR irradiation of the tumor-targeted FPc NPs can cause phototherapeutic effects in vitro and in vivo through excessive local heating, demonstrating potential of phthalocyanine-aggregated nanoparticles as an all-organic NIR nanoabsorber for hyperthermia. English IVYSPRING INT PUBL 808-NM DIODE-LASER CARBON NANOTUBES CELL DESTRUCTION DISC DYE POLYCARBONATE ABLATION AGENTS STATE Phthalocyanine-Aggregated Polymeric Nanoparticles as Tumor-Homing Near-Infrared Absorbers for Photothermal Therapy of Cancer Article 10.7150/thno.4133 1 THERANOSTICS, v.2, no.9, pp.871 - 879 THERANOSTICS 2 9 871 879 scie scopus 000309885800006 2-s2.0-84872398522 Medicine, Research & Experimental Research & Experimental Medicine Article 808-NM DIODE-LASER CARBON NANOTUBES CELL DESTRUCTION DISC DYE POLYCARBONATE ABLATION AGENTS STATE Phototermal therapy Phthalocyanine Near-infrared photonics Tumor targeting Hyperthermia Nanoparticles