Cho, Jung-Kyo Chun, ChanJu Kuh, Hyo-Jeong Song, Soo-Chang 2024-01-20T14:05:11Z 2024-01-20T14:05:11Z 2021-09-05 2012-08 0939-6411 https://pubs.kist.re.kr/handle/201004/129023 The objective of this study is to develop an effective polymer therapeutics involving camptothecin (CPT) with enhanced efficacy and lessened systemic side-toxicity for cancer treatment. Polymer-CPT conjugates (PCCs), which consisted of CPT-20-glycinate and poly(organophosphazene) bearing carboxylic acid, were synthesized, characterized for physicochemical properties, in vitro degradation and CPT release behaviors from the PCC, and evaluated their anticancer activity. The aqueous solutions of all these PCCs showed a thermo-responsive sol-gel transition behavior for injectable application near room temperature. The CPT incorporated into the hydrogel was proven to be stable in vitro over 15 days. The in vitro cytotoxicity of the PCC was verified to be effective against four kinds of human cancer cell lines. The in vivo anticancer activity study with HT-29 colon cancer cell xenografted mice showed that the intratumorally injected PCC hydrogel inhibited the tumor growth more effectively relative to CPT alone (-29% vs. 130% in tumor size). Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved. English ELSEVIER SCIENCE BV POLYMER THERAPEUTICS SPACER GROUPS CAMPTOTHECIN CANCER POLYPHOSPHAZENES EFFICACY DELIVERY Injectable poly(organophosphazene)-camptothecin conjugate hydrogels: Synthesis, characterization, and antitumor activities Article 10.1016/j.ejpb.2012.04.008 1 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v.81, no.3, pp.582 - 590 EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 81 3 582 590 scie scopus 000307040900015 2-s2.0-84863774652 Pharmacology & Pharmacy Pharmacology & Pharmacy Article POLYMER THERAPEUTICS SPACER GROUPS CAMPTOTHECIN CANCER POLYPHOSPHAZENES EFFICACY DELIVERY Antitumor activity Poly(organophosphazene) Thermosensitive hydrogel Polymer-drug conjugate Stability of camptothecin