Cha, Kwang Hyun Song, Dae-Geun Kim, Sang Min Pan, Cheol-Ho 2024-01-20T14:30:47Z 2024-01-20T14:30:47Z 2021-09-05 2012-07-25 0021-8561 https://pubs.kist.re.kr/handle/201004/129054 Green tea, coffee, and gomchui (Ligularia fischeri) tea, which are rich in polyphenols, may exhibit antiobesity effects by inhibiting pancreatic lipase. However, the bioavailability of some polyphenols is poor due to either degradation or absorption difficulties in the gastrointestinal tract, thus making their beneficial effects doubtful. This study was conducted,to evaluate the inhibitory effect of three beverages on lipolysis and the contribution of their major polyphenols during simulated digestion. During simulated digestion, gomchui tea was the most potent at inhibiting gastrointestinal lipolysis, whereas green tea was the least potent. The strongest lipase inhibitor among purified major polyphenols was a green tea polyphenol, (-)-epigallocatechin gallate (EGCG, IC50 = 1.8 +/- 0.57 mu M), followed by di-O-caffeoylquinic acid isomers (DCQA, IC50 from 12.7 +/- 4.5 to 404 +/- 23 mu M), which are gomchui tea polyphenols. However, the stability of DCQA was greater than that of EGCG when subjected to simulated digestion. Taken together, gomchui tea, which has DCQA as the major polyphenol, showed stronger lipolysis inhibitory activity during simulated digestion compared to both green tea and coffee. English AMER CHEMICAL SOC LIPASE IN-VITRO PANCREATIC LIPASE CHLOROGENIC ACID ANTIOXIDANT ACTIVITY BLACK TEA CATECHINS BIOAVAILABILITY INGESTION IDENTIFICATION INFLAMMATION Inhibition of Gastrointestinal Lipolysis by Green Tea, Coffee, and Gomchui (Ligularia fischeri) Tea Polyphenols during Simulated Digestion Article 10.1021/jf301047f 1 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.60, no.29, pp.7152 - 7157 JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60 29 7152 7157 scie scopus 000306724300009 2-s2.0-84864366189 Agriculture, Multidisciplinary Chemistry, Applied Food Science & Technology Agriculture Chemistry Food Science & Technology Article LIPASE IN-VITRO PANCREATIC LIPASE CHLOROGENIC ACID ANTIOXIDANT ACTIVITY BLACK TEA CATECHINS BIOAVAILABILITY INGESTION IDENTIFICATION INFLAMMATION EGCG DCQA lipase inhibition green tea coffee Ligularia fischeri simulated digestion