Cha, Ji Hyeon Lee, Sang Hoon Lee, Sheen-Woo Park, Kyeongsoon Moon, Dae Hyuk Kim, Kwangmeyung Biswal, Sandip 2024-01-20T14:31:40Z 2024-01-20T14:31:40Z 2021-09-05 2012-07 1229-6929 https://pubs.kist.re.kr/handle/201004/129094 Objective: To evaluate the potential and correlation between near-infrared fluorescence (NIRF) imaging using cyanine 5.5 conjugated with hydrophobically modified glycol chitosan nanoparticles (HGC-Cy5.5) and F-18-fluorodeoxyglucose-positron emission tomography (F-18-FDG-PET) imaging of collagen-induced arthritis (CIA). Materials and Methods: We used 10 CIA and 3 normal mice. Nine days after the injecting collagen twice, microPET imaging was performed 40 minutes after the intravenous injection of 9.3 MBq F-18-FDG in 200 mu L PBS. One day later, NIRF imaging was performed two hours after the intravenous injection of HGC-cy5.5 (5 mg/kg). We assessed the correlation between these two modalities in the knees and ankles of CIA mice. Results: The mean standardized uptake values of F-18-FDG for knees and ankles were 1.68 +/- 0.76 and 0.79 +/- 0.71, respectively, for CIA mice; and 0.57 +/- 0.17 and 0.54 +/- 0.20 respectively for control mice. From the NIRF images, the total photon counts per 30 mm(2) for knees and ankles were 2.32 +/- 1.54 x 10(5) and 2.75 +/- 1.51 x 10(5), respectively, for CIA mice, and 1.22 +/- 0.27 x 10(5) and 0.88 +/- 0.24 x 10(5), respectively, for control mice. These two modalities showed a moderate correlation for knees (r = 0.604, p = 0.005) and ankles (r = 0.464, p = 0.039). Moreover, both HGC-Cy5.5 (p = 0.002) and F-18-FDG-PET (p = 0.005) imaging also showed statistically significant differences between CIA and normal mice. Conclusion: NIRF imaging using HGC-Cy5.5 was moderately correlated with F-18-FDG-PET imaging in the CIA model. As such, HGC-Cy5.5 imaging can be used for the early detection of rheumatoid arthritis. English KOREAN RADIOLOGICAL SOC NEAR-INFRARED FLUORESCENCE RHEUMATOID-ARTHRITIS DISEASE-ACTIVITY F-18-FDG PET BLOOD-FLOW MODEL PATHOGENESIS LIPOSOMES ANTIBODY DYES Assessment of Collagen-Induced Arthritis Using Cyanine 5.5 Conjugated with Hydrophobically Modified Glycol Chitosan Nanoparticles: Correlation with F-18-Fluorodeoxyglucose Positron Emission Tomography Data Article 10.3348/kjr.2012.13.4.450 1 KOREAN JOURNAL OF RADIOLOGY, v.13, no.4, pp.450 - 461 KOREAN JOURNAL OF RADIOLOGY 13 4 450 461 scie scopus kci ART001685254 000306396600009 2-s2.0-84863304505 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging Article NEAR-INFRARED FLUORESCENCE RHEUMATOID-ARTHRITIS DISEASE-ACTIVITY F-18-FDG PET BLOOD-FLOW MODEL PATHOGENESIS LIPOSOMES ANTIBODY DYES HGC-Cy5.5 F-18-FDG PET Near-infrared fluorescence imaging Rheumatoid arthritis