Na, Hee-Kyung Kim, Mi-Hee Park, Kihyun Ryoo, Soo-Ryoon Lee, Kyung Eun Jeon, Hyesung Ryoo, Ryong Hyeon, Changbong Min, Dal-Hee 2024-01-20T14:32:52Z 2024-01-20T14:32:52Z 2021-09-05 2012-06-11 1613-6810 https://pubs.kist.re.kr/handle/201004/129149 Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug-delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post-transcriptional gene silencing, so-called RNA interference. Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity. English WILEY-V C H VERLAG GMBH SMALL INTERFERING RNA ENDOTHELIAL GROWTH-FACTOR GENE CELLS THERAPEUTICS CANCER RESISTANT PLANTS Efficient Functional Delivery of siRNA using Mesoporous Silica Nanoparticles with Ultralarge Pores Article 10.1002/smll.201200028 1 SMALL, v.8, no.11, pp.1752 - 1761 SMALL 8 11 1752 1761 scie scopus 000304817700016 2-s2.0-84861880834 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article SMALL INTERFERING RNA ENDOTHELIAL GROWTH-FACTOR GENE CELLS THERAPEUTICS CANCER RESISTANT PLANTS cancer therapy drug delivery mesoporous materials nanoparticles RNA interference