Lee, Sangmin Lee, Seung-Young Park, Sangjin Ryu, Ju Hee Na, Jin Hee Koo, Heebeom Lee, Kyung Eun Jeon, Hyesung Kwon, Ick Chan Kim, Kwangmeyung Jeong, Seo Young 2024-01-20T14:34:29Z 2024-01-20T14:34:29Z 2021-09-04 2012-06 1616-5187 https://pubs.kist.re.kr/handle/201004/129232 To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50?wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near-infrared fluorescence images reveal that PEG-PE/PC liposomes display high tumor accumulation in tumor-bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome-based drug carriers. English WILEY-V C H VERLAG GMBH PHOTODYNAMIC THERAPY SURFACE-CHARGE GENE DELIVERY NANOPARTICLES PEGYLATION DIAGNOSIS In vivo NIRF Imaging of Tumor Targetability of Nanosized Liposomes in Tumor-Bearing Mice Article 10.1002/mabi.201200001 1 MACROMOLECULAR BIOSCIENCE, v.12, no.6, pp.849 - 856 MACROMOLECULAR BIOSCIENCE 12 6 849 856 scie scopus 000304711200015 2-s2.0-84861763135 Biochemistry & Molecular Biology Materials Science, Biomaterials Polymer Science Biochemistry & Molecular Biology Materials Science Polymer Science Article PHOTODYNAMIC THERAPY SURFACE-CHARGE GENE DELIVERY NANOPARTICLES PEGYLATION DIAGNOSIS drug delivery systems imaging liposomes PEGylation tumor targeting