Lee, Chan Woo Park, Nok Hyun Kim, Jin Woong Um, Byung Hun Shpatov, A. V. Shults, E. E. Sorokina, I. V. Popov, S. A. 2024-01-20T15:00:40Z 2024-01-20T15:00:40Z 2022-01-25 2012-05 1068-1620 https://pubs.kist.re.kr/handle/201004/129272 Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid). English MAIK NAUKA/INTERPERIODICA/SPRINGER Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives Article 10.1134/S1068162012030028 1 RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, v.38, no.3, pp.328 - 334 RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 38 3 328 334 N scie scopus 000304408900013 2-s2.0-84865457787 Biochemistry & Molecular Biology Chemistry, Organic Biochemistry & Molecular Biology Chemistry Review ANTI-AIDS AGENTS MATRIX METALLOPROTEINASES NUCLEAR TRANSLOCATION ACID-DERIVATIVES KAPPA-B EXPRESSION INDUCTION BETULIN GENE CONSTITUENTS collagenase-1 triterpenoids dihydroquercetin photoageing interleukin-8