Lim, Chang-Keun Shin, Jiyoung Kwon, Ick Chan Jeong, Seo Young Kim, Sehoon 2024-01-20T15:01:41Z 2024-01-20T15:01:41Z 2021-09-04 2012-05 1043-1802 https://pubs.kist.re.kr/handle/201004/129313 A novel iodinated chitosan-backboned conjugate (GC-I-Ce6) was designed and prepared to fabricate self-assembled biopolymeric nanoparticles with heavy atom-effected enhanced singlet oxygen generation as well as biological merits. The heavy atom-rich nature of the hydrophobic particle interior was characterized with X-ray absorption and the modified photophysical properties of a chemically embedded photosensitizer, chlorin e6 (Ce6). From the comparative spectroscopic studies as well as cellular and animal experiments, it has been shown that the self-assembled GC I Ce6 nanoparticles have enhanced capability of singlet oxygen generation by the intraparticle heavy-atom effect, along with high tumor targetability in vitro and in vivo thanks to the glycol chitosan-surfaced exterior with biocompatible, positively charged and tumor-homing characteristics. Actual efficacy improvement in the photodynamic therapy of a human breast cancer cell line (MDA-MB-231) demonstrates potential applications. of our photophysically and pharmaceutically motivated hybrid bioconjugate approach for nanomedicine applications. English AMER CHEMICAL SOC MODIFIED SILICA NANOPARTICLES PHOTODYNAMIC THERAPY DELIVERY PORPHYRIN EFFICACY Iodinated Photosensitizing Chitosan: Self-Assembly into Tumor-Homing Nanoparticles with Enhanced Singlet Oxygen Generation Article 10.1021/bc300012g 1 BIOCONJUGATE CHEMISTRY, v.23, no.5, pp.1022 - 1028 BIOCONJUGATE CHEMISTRY 23 5 1022 1028 scie scopus 000304027500015 2-s2.0-84861149172 Biochemical Research Methods Biochemistry & Molecular Biology Chemistry, Multidisciplinary Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article MODIFIED SILICA NANOPARTICLES PHOTODYNAMIC THERAPY DELIVERY PORPHYRIN EFFICACY