Lee, Dong-Eun Koo, Heebeom Sun, In-Cheol Ryu, Ju Hee Kim, Kwangmeyung Kwon, Ick Chan 2024-01-20T15:03:09Z 2024-01-20T15:03:09Z 2021-09-05 2012-04 0306-0012 https://pubs.kist.re.kr/handle/201004/129370 Nanomedicine is the biomedical application of nanoscale materials for diagnosis and therapy of disease. Recent advances in nanotechnology and biotechnology have contributed to the development of multifunctional nanoparticles as representative nanomedicine. They were initially developed to enable the target-specific delivery of imaging or therapeutic agents for biomedical applications. Due to their unique features including multifunctionality, large surface area, structural diversity, and long circulation time in blood compared to small molecules, nanoparticles have emerged as attractive preferences for optimized therapy through personalized medicine. Multimodal imaging and theragnosis are the cutting-edge technologies where the advantages of nanoparticles are maximized. Because each imaging modality has its pros and cons, the integration of several imaging agents with different properties into multifunctional nanoparticles allows precise and fast diagnosis of disease through synergetic multimodal imaging. Moreover, nanoparticles are not only used for molecular imaging but also applied to deliver therapeutic agents to the disease site in order to accomplish the simultaneous imaging and therapy called theragnosis. This tutorial review will highlight the recent advances in the development of multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine. English ROYAL SOC CHEMISTRY IRON-OXIDE NANOPARTICLES IN-VIVO DRUG-DELIVERY CARBON NANOTUBES MAGNETIC NANOPARTICLES PHOTOTHERMAL THERAPY CONTRAST AGENTS PHOTODYNAMIC THERAPY SILICA NANOPARTICLES GOLD NANOPARTICLES Multifunctional nanoparticles for multimodal imaging and theragnosis Article 10.1039/c2cs15261d 1 CHEMICAL SOCIETY REVIEWS, v.41, no.7, pp.2656 - 2672 CHEMICAL SOCIETY REVIEWS 41 7 2656 2672 scie scopus 000301354900010 2-s2.0-84863338346 Chemistry, Multidisciplinary Chemistry Review IRON-OXIDE NANOPARTICLES IN-VIVO DRUG-DELIVERY CARBON NANOTUBES MAGNETIC NANOPARTICLES PHOTOTHERMAL THERAPY CONTRAST AGENTS PHOTODYNAMIC THERAPY SILICA NANOPARTICLES GOLD NANOPARTICLES Drug Delivery Systems Diagnostic Imaging Nanomedicine