Kojima, Chie Cho, So-Hye Higuchi, Eiji 2024-01-20T15:03:16Z 2024-01-20T15:03:16Z 2021-09-05 2012-04 0922-6168 https://pubs.kist.re.kr/handle/201004/129375 Both therapy and diagnosis, theragnosis, are indispensable for personalized medicine. Gold nanoparticles (Au NPs) have photochemical properties and attenuate X-rays, which are useful for photothermal therapy and X-ray computed tomography (CT) imaging, respectively. Polyethylene glycol (PEG)-modified dendrimers (PEGylated dendrimers) have been used as drug carriers with prolonged blood circulation. In this study, Au NP-loaded PEGylated dendrimers were prepared as agents for photothermal therapy and CT imaging. Au NPs were grown in the PEGylated dendrimer by adding gold ions and reductants under various conditions to improve the properties. Both size and surface plasmon absorption of the Au NPs increased, dependent on the seeding growth conditions. Au NPs with near infrared absorption were also prepared by seeding growth from Au NP-loaded PEGylated dendrimers using formaldehyde. The Au NPs thus grown showed enhanced photothermogenic properties and CT intensities, enabling efficient photocytotoxicity and the enhancement of the blood pool in mice by CT imaging. Therefore, Au NP-loaded PEGylated dendrimers are a potential agent for theragnosis. English SPRINGER RAY COMPUTED-TOMOGRAPHY BIOMEDICAL APPLICATIONS CONTRAST AGENT POLY(AMIDOAMINE) DENDRIMERS DRUG-DELIVERY ATTENUATION CATALYSIS ABILITY DESIGN HEAT Gold nanoparticle-loaded PEGylated dendrimers for theragnosis Article 10.1007/s11164-011-0466-9 1 RESEARCH ON CHEMICAL INTERMEDIATES, v.38, no.6, pp.1279 - 1289 RESEARCH ON CHEMICAL INTERMEDIATES 38 6 1279 1289 scie scopus 000302146600012 Chemistry, Multidisciplinary Chemistry Review RAY COMPUTED-TOMOGRAPHY BIOMEDICAL APPLICATIONS CONTRAST AGENT POLY(AMIDOAMINE) DENDRIMERS DRUG-DELIVERY ATTENUATION CATALYSIS ABILITY DESIGN HEAT Gold nanoparticle Dendrimer Photothermal therapy CT imaging Seeding growth PEGylation