Han, Hyung-Seop Kim, Young-Yul Kim, Yu-Chan Cho, Sung-Youn Cha, Pil-Ryung Seok, Hyun-Kwang Yang, Seok-Jo 2024-01-20T15:03:47Z 2024-01-20T15:03:47Z 2021-09-05 2012-04 1598-9623 https://pubs.kist.re.kr/handle/201004/129396 The purposes of this preliminary study were to investigate the effect of increased Ca contents (5-10 wt% Ca) in Mg-Ca alloy on the mechanical properties and osseous healing rate in a standard rat defect model. Mechanical tests were performed using a compression system followed by qualitative histological analysis using the hemotoxylin and eosin (H&E) staining method and quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase PCR). Mg-Ca alloy degraded fast in vivo while displaying a high level of the bone formation markersOC and ALP. Favorablemechanical strength properties were displayed as Ca content increased from 5 wt% to 10 wt% to show its potential to be considered as a load bearing implant material. The resultfrom this study suggests that the developed Mg-Ca alloy has the potential to serve as a biocompatible load bearing implant material that is degradable and possibly osteoconductive. English KOREAN INST METALS MATERIALS IN-VIVO CORROSION SCAFFOLDS EXPRESSION BEHAVIOR SURFACE STENTS CELLS Bone formation within the vicinity of biodegradable magnesium alloy implant in a rat femur model Article 10.1007/s12540-012-2007-5 1 METALS AND MATERIALS INTERNATIONAL, v.18, no.2, pp.243 - 247 METALS AND MATERIALS INTERNATIONAL 18 2 243 247 scie scopus kci 000303532600007 2-s2.0-84863817539 Materials Science, Multidisciplinary Metallurgy & Metallurgical Engineering Materials Science Metallurgy & Metallurgical Engineering Article IN-VIVO CORROSION SCAFFOLDS EXPRESSION BEHAVIOR SURFACE STENTS CELLS biomaterials casting mechanical properties bone compression test