Shin, Kyoungjin Chin, Jungwook Hahn, Dongyup Lee, Jaehwan Hwang, Hoosang Won, Dong Hwan Ham, Jungyeob Choi, Hyukjae Kang, Eunsoo Kim, Hiyoung Ju, Moon Kyeong Nam, Sang-Jip Kang, Heonjoong 2024-01-20T15:04:18Z 2024-01-20T15:04:18Z 2021-08-31 2012-04 0039-128X https://pubs.kist.re.kr/handle/201004/129418 Three new steroids 3-oxocholest-1,22-dien-12 beta-ol (1), 3-oxocholest-1,4-dien-20 beta-ol (2), 3-oxocholest-1,4-dien-12 beta-ol (3), and three known steroids (20S)-20-Hydroxyergosta-1,4,24(28)-trien-3-one (4)[7a], 5 alpha,8 alpha-Epidioxycholesta-6,22-dien-3 beta-ol (5) [10] and 5-cholestene-3 beta,12 beta-diol (6) 1111 were isolated from a soft coral Dendronephthya gigantea. Their chemical structures and relative stereochemistry were elucidated by the analysis of HRMS and 2-D NMR spectroscopic data. The steroids 1 and 2 showed notable inhibitory activity against farnesoid X-activated receptor (FXR) with IC50's 14 and 15 mu M. (C) 2012 Elsevier Inc. All rights reserved. English ELSEVIER SCIENCE INC STRUCTURE ELUCIDATION URSODEOXYCHOLIC ACID Sterols from a soft coral, Dendronephthya gigantea as farnesoid X-activated receptor antagonists Article 10.1016/j.steroids.2011.12.027 1 STEROIDS, v.77, no.5, pp.355 - 359 STEROIDS 77 5 355 359 scie scopus 000303084000001 2-s2.0-84862790074 Biochemistry & Molecular Biology Endocrinology & Metabolism Biochemistry & Molecular Biology Endocrinology & Metabolism Article STRUCTURE ELUCIDATION URSODEOXYCHOLIC ACID Cholestasis Dendronephthya gigantea Farnesoid X-activated receptor