Lee, Woojung Yoon, Goo Hwang, Ye Ran Kim, Yong Kee Su-Nam Kim 2024-01-20T15:04:28Z 2024-01-20T15:04:28Z 2021-09-05 2012-03-31 1976-6696 https://pubs.kist.re.kr/handle/201004/129423 Protein tyrosine phosphatase 1B (PTP1B) is important in the regulation of metabolic diseases and has emerged as a promising signaling target. Previously, we reported the PTP1B inhibitory activity of Rheum undulatum (RU). In the present study, we investigated the metabolic regulatory effects of RU in a high-fat diet (HFD) model. RU treatment significantly blocked body weight gain, which was accompanied by a reduction of feed efficiency. In addition, it led to a reduction of liver weight mediated by overexpression of PPAR alpha and CPT1 in the liver, and an increase in the expression of adiponectin, aP2, and UCP3 in adipose tissue responsible for the reduction of total and LDL-cholesterol levels. Chrysophanol and physcion from RU significantly inhibited PTP1B activity and strongly enhanced insulin sensitivity. Altogether, our findings strongly suggest that 2 compounds are novel PTP1B inhibitors and might be considered as anti-obesity agents that are effective for suppressing body weight gain and improving lipid homeostasis. [BMB reports 2012; 45(3): 141-146] English KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY INSULIN SENSITIVITY DRUG TARGETS IN-VIVO DERIVATIVES RESISTANCE STILBENE OBESITY ACID Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition Article 10.5483/BMBRep.2012.45.3.141 1 BMB REPORTS, v.45, no.3, pp.141 - 146 BMB REPORTS 45 3 141 146 scie scopus kci ART001644127 000302257100002 2-s2.0-84861844196 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article INSULIN SENSITIVITY DRUG TARGETS IN-VIVO DERIVATIVES RESISTANCE STILBENE OBESITY ACID Chrysophanol Obesity Physcion PTP1B Rheum undulatum