Weon, Jin Bae Kim, Chul Young Yang, Hye Jin Ma, Choong Je 2024-01-20T15:04:50Z 2024-01-20T15:04:50Z 2022-01-25 2012-03 0253-6269 https://pubs.kist.re.kr/handle/201004/129436 Ten compounds were isolated from the 80% methanol extract of roots of Cynanchum paniculatum Kitagawa (Asclepiadaceae) and identified as paeonol (1), 4-acetylphenol (2), 2,5-dihydroxy-4-methoxyacetophenone (3), 2,3-dihydroxy-4-methoxyacetophenone (4), acetoveratrone (5), 2,5-dimethoxyhydroquinone (6), vanillic acid (7), resacetophenone (8), m-acetylphenol (9) and 3,5-dimethoxyhydroquinone (10). The protective effect of compounds 1-10 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was evaluated. Among them, compound 4 showed a relatively effective protection of 47.55% (at 10 mu M). This result suggested that compounds 4 had neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells. English PHARMACEUTICAL SOC KOREA Neuroprotective compounds isolated from Cynanchum paniculatum Article 10.1007/s12272-012-0404-4 1 ARCHIVES OF PHARMACAL RESEARCH, v.35, no.4, pp.617 - 621 ARCHIVES OF PHARMACAL RESEARCH 35 4 617 621 N scie scopus kci ART001654579 000303532800005 2-s2.0-84862853953 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article NEURONAL CELL-LINE OXIDATIVE STRESS GLUTAMATE FRACTION Cynanchum paniculatum Kitagawa Neuroprotective activity 2,3-Dihydroxy-4methoxyacetophenone