Yuk, Soon Hong Oh, Keun Sang Kim, Seung Ki Lee, Jin Ho Cho, Sun Hang Kim, Kwangmeyung Jeon, Hyesung Kwon, Ick Chan 2024-01-20T15:05:35Z 2024-01-20T15:05:35Z 2021-09-05 2012-03 1598-5032 https://pubs.kist.re.kr/handle/201004/129469 The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed. English POLYMER SOC KOREA GH-DEFICIENT PATIENTS GROWTH-HORMONE GH COPOLYMER FUSION ENCAPSULATION MICROSPHERES SPECTROSCOPY STABILITY BILAYER SYSTEMS Multi-core vesicle nanoparticles for controlled delivery of protein drug Article 10.1007/s13233-012-0053-y 1 MACROMOLECULAR RESEARCH, v.20, no.3, pp.309 - 312 MACROMOLECULAR RESEARCH 20 3 309 312 scie scopus kci ART001643265 000302262000013 2-s2.0-84862189747 Polymer Science Polymer Science Article GH-DEFICIENT PATIENTS GROWTH-HORMONE GH COPOLYMER FUSION ENCAPSULATION MICROSPHERES SPECTROSCOPY STABILITY BILAYER SYSTEMS human growth hormone Pluronic/PEG composite NPs multi-core vesicle NPs peptide drug sustained release