Kim, Jang Il Lee, Beom Suk Chun, Chan Cho, Jung-Kyo Kim, Sang-Yoon Song, Soo-Chang 2024-01-20T15:05:58Z 2024-01-20T15:05:58Z 2021-09-04 2012-03 0142-9612 https://pubs.kist.re.kr/handle/201004/129489 The long-term theranostic hydrogel system for solid tumors was prepared via simple physical mixing, which consisted of three major parts: the thermosensitive/biodegradable poly(organophosphazene) hydrogel, PEGylated cobalt ferrite nanoparticles, and paclitaxel (PTX). The PEGylated cobalt ferrite nanoparticles showed extremely low cytotoxicity due to the surface modification using PEG chains. The long-term theranostic hydrogel system showed adequate properties to be used for long-term MR theragnosis. In particular, the theranostic hydrogel gradually degraded over 28 days, and the PTX was sustainedly released out from the theranostic hydrogel over the same period in vitro. Furthermore, the in vivo efficacy of long-term MR theragnosis using the theranostic hydrogel system was estimated successfully over 3 weeks by using high field (4.7 T) animal MRI and solid tumor-bearing mice. Based on our results, we expect that this system can supply multiple data regarding a) the progress of therapy and b) the treatment processes via one- or two-time i.t, administration for cases in which surgical approaches are difficult to apply. Meanwhile, cancer patients can be free from the pain of multiple surgical treatments and have the advantage of therapy through a simple it, administration. (C) 2011 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD SUPERPARAMAGNETIC IRON-OXIDE I CLINICAL-EVALUATION INTRATUMORAL INJECTION MAGNETIC-PROPERTIES CONTRAST-MEDIUM DRUG-DELIVERY NANOPARTICLES DOXORUBICIN PHARMACOKINETICS ANGIOGRAPHY Long-term theranostic hydrogel system for solid tumors Article 10.1016/j.biomaterials.2011.11.083 1 BIOMATERIALS, v.33, no.7, pp.2251 - 2259 BIOMATERIALS 33 7 2251 2259 scie scopus 000300473900032 2-s2.0-84855725646 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article SUPERPARAMAGNETIC IRON-OXIDE I CLINICAL-EVALUATION INTRATUMORAL INJECTION MAGNETIC-PROPERTIES CONTRAST-MEDIUM DRUG-DELIVERY NANOPARTICLES DOXORUBICIN PHARMACOKINETICS ANGIOGRAPHY Phosphazene Long-term theragnosis Contrast agents Sustained release Drug delivery system