Yi, Hyunjung Ghosh, Debadyuti Ham, Moon-Ho Qi, Jifa Barone, Paul W. Strano, Michael S. Belcher, Angela M. 2024-01-20T15:30:34Z 2024-01-20T15:30:34Z 2021-08-31 2012-03 1530-6984 https://pubs.kist.re.kr/handle/201004/129511 Second near-infrared (NIR) window light (950-1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 mu g/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas. English AMER CHEMICAL SOC IN-VIVO QUANTUM DOTS MEMBRANE ANTIGEN MICE NANOPARTICLES PEPTIDES CANCER CELLS MOLECULES SURGERY M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors Article 10.1021/nl2031663 1 NANO LETTERS, v.12, no.3, pp.1176 - 1183 NANO LETTERS 12 3 1176 1183 scie scopus 000301406800011 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article IN-VIVO QUANTUM DOTS MEMBRANE ANTIGEN MICE NANOPARTICLES PEPTIDES CANCER CELLS MOLECULES SURGERY Second near-infrared window fluorescence single-walled carbon nanotubes molecular imaging hybrid imaging probes nanobiotechnology