Devegowda, Vani Nelamane Seo, Seon Hee Pae, Ae Nim Nam, Ghilsoo Choi, Kyung Il 2024-01-20T15:31:06Z 2024-01-20T15:31:06Z 2021-09-04 2012-02-20 0253-2964 https://pubs.kist.re.kr/handle/201004/129534 Promising anticancer compounds of the type 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The relationships between the structure and the anticancer activity, covering all tested cancer cell lines, revealed that the compound 5c with 2,4-dimethylphenyl substituent at R-2 was the most potent with the IC50 values in the range as low as 0.16 to 0.40 mu M. English KOREAN CHEMICAL SOC INHIBITORS AGENTS POTENT Synthesis of 1,6-Disubstituted 4,5,6,7-Tetrahydropyrazolo[3,4-c]pyridin-7-one Derivatives and Evaluation of Their Anticancer Activity Article 10.5012/bkcs.2012.33.2.647 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.2, pp.647 - 650 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 33 2 647 650 scie scopus kci ART001642536 000301330900052 2-s2.0-84857483295 Chemistry, Multidisciplinary Chemistry Article INHIBITORS AGENTS POTENT Tetrahydropyrazolopyridinone 3-Aminopyrazole Anti-proliferative activity Anticancer drugs