Kim, Jong-Ho Bae, Sang Mun Na, Moon-Hee Shin, Hyeri Yang, Yu Jin Min, Kyung Hyun Choi, Ki Young Kim, Kwangmeyung Park, Rang-Woon Kwon, Ick Chan Lee, Byung-Heon Hoffman, Allan S. Kim, In-San 2024-01-20T15:31:21Z 2024-01-20T15:31:21Z 2021-09-05 2012-02-10 0168-3659 https://pubs.kist.re.kr/handle/201004/129544 Macromolecular nanoparticles can extravasate and accumulate within tumor tissues via the passive targeting system, reflecting enhanced permeability and the retention effect. However, the unsatisfactory tumor therapeutic efficacy of the passive-targeting system, attributable to the retention of extravasated nanoparticles in the vicinity of tumor vessels, argues that a new system that facilitates intracellular delivery of nanoparticles within tumors is needed. Here, we developed hydrophobically modified glycol chitosan (HGC) nanoparticles conjugated with interleukin-4 receptor (IL-4R) binding peptides, termed I4R, and tested them in mice bearing IL-4R-positive tumors. These HGC-I4R nanoparticles exhibited enhanced IL-4R-dependent cellular uptake in tumors compared to nonconjugated nanoparticles, leading to better therapeutic and imaging efficacy. We conclude that I4R facilitates and enhances cellular uptake of nanoparticles in tumor tissues. This study suggests that the intracelluar uptake of nanoparticles in tumors is an essential factor to consider in designing nanoparticles for tumor-targeted drug delivery and imaging. (C) 2011 Elsevier B.V. All rights reserved. English ELSEVIER GLYCOL CHITOSAN NANOPARTICLES INTERLEUKIN-4 RECEPTOR CANCER-THERAPY AFFINITY INTERNALIZATION LOCALIZATION CHEMOTHERAPY VASCULATURE DOXORUBICIN EXPRESSION Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues Article 10.1016/j.jconrel.2011.09.070 1 JOURNAL OF CONTROLLED RELEASE, v.157, no.3, pp.493 - 499 JOURNAL OF CONTROLLED RELEASE 157 3 493 499 scie scopus 000301980900021 2-s2.0-84857374141 Chemistry, Multidisciplinary Pharmacology & Pharmacy Chemistry Pharmacology & Pharmacy Article GLYCOL CHITOSAN NANOPARTICLES INTERLEUKIN-4 RECEPTOR CANCER-THERAPY AFFINITY INTERNALIZATION LOCALIZATION CHEMOTHERAPY VASCULATURE DOXORUBICIN EXPRESSION Tumor targeting Nanoparticles Homing peptide Cancer therapy Cancer imaging