Lee, Sukchan Ahmed, Touqeer Lee, Soojung Kim, Huisu Choi, Sukwoo Kim, Duk-Soo Kim, Sang Jeong Cho, Jeiwon Shin, Hee-Sup 2024-01-20T15:32:55Z 2024-01-20T15:32:55Z 2021-09-04 2012-02 1097-6256 https://pubs.kist.re.kr/handle/201004/129624 The mediodorsal thalamic nucleus has been implicated in the control of memory processes. However, the underlying neural mechanism remains unclear. Here we provide evidence for bidirectional modulation of fear extinction by the mediodorsal thalamic nucleus. Mice with a knockout or mediodorsal thalamic nucleus-specific knockdown of phospholipase C beta 4 exhibited impaired fear extinction. Mutant mediodorsal thalamic nucleus neurons in slices showed enhanced burst firing accompanied by increased T-type Ca2+ currents; blocking of T channels in vivo rescued the fear extinction. Tetrode recordings in freely moving mice revealed that, during extinction, the single-spike (tonic) frequency of mediodorsal thalamic nucleus neurons increased in wild-type mice, but was static in mutant mice. Furthermore, tonic-evoking microstimulations of the mediodorsal thalamic nucleus, contemporaneous with the extinction tones, rescued fear extinction in mutant mice and facilitated it in wild-type mice. In contrast, burst-evoking microstimulation suppressed extinction in wild-type mice, mimicking the mutation. These results suggest that the firing mode of the mediodorsal thalamic nucleus is critical for the modulation of fear extinction. English NATURE PUBLISHING GROUP MEDIAL PREFRONTAL CORTEX POSTTRAUMATIC-STRESS-DISORDER CONDITIONED FEAR THALAMOCORTICAL RELAY NUCLEUS AMYGDALA LESIONS MEMORY RATS ATTENTION Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice Article 10.1038/nn.2999 1 NATURE NEUROSCIENCE, v.15, no.2, pp.308 - 314 NATURE NEUROSCIENCE 15 2 308 314 scie scopus 000299603500023 2-s2.0-84856241783 Neurosciences Neurosciences & Neurology Article MEDIAL PREFRONTAL CORTEX POSTTRAUMATIC-STRESS-DISORDER CONDITIONED FEAR THALAMOCORTICAL RELAY NUCLEUS AMYGDALA LESIONS MEMORY RATS ATTENTION