Huh, Yeowool Bhatt, Rushi Jung, DaeHyun Shin, Hee-sup Cho, Jeiwon 2024-01-20T15:33:06Z 2024-01-20T15:33:06Z 2021-09-05 2012-01-23 1932-6203 https://pubs.kist.re.kr/handle/201004/129631 Thalamocortical (TC) neurons are known to relay incoming sensory information to the cortex via firing in tonic or burst mode. However, it is still unclear how respective firing modes of a single thalamic relay neuron contribute to pain perception under consciousness. Some studies report that bursting could increase pain in hyperalgesic conditions while others suggest the contrary. However, since previous studies were done under either neuropathic pain conditions or often under anesthesia, the mechanism of thalamic pain modulation under awake conditions is not well understood. We therefore characterized the thalamic firing patterns of behaving mice in response to nociceptive pain induced by inflammation. Our results demonstrated that nociceptive pain responses were positively correlated with tonic firing and negatively correlated with burst firing of individual TC neurons. Furthermore, burst properties such as intra-burst-interval (IntraBI) also turned out to be reliably correlated with the changes of nociceptive pain responses. In addition, brain stimulation experiments revealed that only bursts with specific bursting patterns could significantly abolish behavioral nociceptive responses. The results indicate that specific patterns of bursting activity in thalamocortical relay neurons play a critical role in controlling long-lasting inflammatory pain in awake and behaving mice. English PUBLIC LIBRARY SCIENCE THETA-BURST STIMULATION DEEP BRAIN-STIMULATION SOMATOSENSORY BARREL CORTEX SPINAL-CORD-INJURY ELECTRICAL-STIMULATION NUCLEUS SUBMEDIUS MECHANICAL ALLODYNIA RECEPTIVE-FIELDS CA2+ CHANNELS MOTOR CORTEX Interactive Responses of a Thalamic Neuron to Formalin Induced Lasting Pain in Behaving Mice Article 10.1371/journal.pone.0030699 1 PLOS ONE, v.7, no.1 PLOS ONE 7 1 scie scopus 000301570600072 2-s2.0-84856194881 Multidisciplinary Sciences Science & Technology - Other Topics Article THETA-BURST STIMULATION DEEP BRAIN-STIMULATION SOMATOSENSORY BARREL CORTEX SPINAL-CORD-INJURY ELECTRICAL-STIMULATION NUCLEUS SUBMEDIUS MECHANICAL ALLODYNIA RECEPTIVE-FIELDS CA2+ CHANNELS MOTOR CORTEX Pain Single Unit recording Thalamus Burst vs. Tonic Neuronal Discharge behaving mouse