Kang, Ki Sung Kim, Hyun Young Yoo, Hye Hyun Piao, Xiang Lan Ham, Jungyeob Yang, Hyun Ok Park, Jeong Hill 2024-01-20T15:33:33Z 2024-01-20T15:33:33Z 2021-09-05 2012-01-01 0960-894X https://pubs.kist.re.kr/handle/201004/129653 The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. RADICAL-SCAVENGING ACTIVITY HEAT-PROCESSED GINSENG DIABETIC-NEPHROPATHY RENAL DAMAGE GINSENOSIDES OXYGEN ANTIOXIDANT REDUCTION RATS RB-1 Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage Article 10.1016/j.bmcl.2011.10.063 1 Bioorganic & Medicinal Chemistry Letters, v.22, no.1, pp.634 - 637 Bioorganic & Medicinal Chemistry Letters 22 1 634 637 scie scopus 000298636700125 2-s2.0-84655161551 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article RADICAL-SCAVENGING ACTIVITY HEAT-PROCESSED GINSENG DIABETIC-NEPHROPATHY RENAL DAMAGE GINSENOSIDES OXYGEN ANTIOXIDANT REDUCTION RATS RB-1 Panax ginseng Renoprotective activity Ginsenoside Sapogenin