An, Yu Ri Yu, So-Yeon Kim, Seung Jun Ha, Jung-Mi Youn, Jong-Phil Kim, Jun-Sub Oh, Moon-Ju Oh, Jung-Hwa Ryu, Jae-Chun Yoon, Seokjoo Jo, Jaehoon Hwang, Seung Yong 2024-01-20T15:34:37Z 2024-01-20T15:34:37Z 2021-09-05 2011-12-31 1738-642X https://pubs.kist.re.kr/handle/201004/129704 Nonylphenol (NP) is considered an endocrine disruptor due to its weak ability to mimic estrogen and in turn disrupt the natural balance of hormones in affected organisms. NP is reported to cause negative health effects in humans, such as hormone abnormalities and inhibition of growth and reproduction. In the present study, we developed a molecular tool for the evaluation of endocrine toxicity in mouse. To identify gene regulation effects of NP, we estimated gene expression in mouse Sertoli (TM4) and germ cell (GC) lines after exposure to NP. We measured the IC(30) value of NP, then exposed the cells to that concentration for 3 hr and 24 hr and used EndoTox Array. The EndoTox Array was manufactured to monitor the endotoxicity of environmental chemicals. This array contains 1306 genes that are influenced in reproductive toxicity or by EDCs. In the expression pattern analysis, 28 genes related to the reproductive process, cell proliferation, and nervous system development were progressively changed over time in NP-exposed cells. The study of gene interaction will increase our understanding of the time-dependent molecular mechanisms of NP. English SPRINGER BISPHENOL-A GENE-EXPRESSION INVOLVEMENT CLEAVAGE VERSICAN RECEPTOR LIVER LINES RATS MICE Identification of time-dependent biomarkers by EndoTox Array in cells exposed to nonylphenol Article 10.1007/s13273-011-0050-9 1 MOLECULAR & CELLULAR TOXICOLOGY, v.7, no.4, pp.399 - 403 MOLECULAR & CELLULAR TOXICOLOGY 7 4 399 403 scie scopus kci other ART001661365 000298789700009 2-s2.0-84863036885 Biochemistry & Molecular Biology Toxicology Biochemistry & Molecular Biology Toxicology Article BISPHENOL-A GENE-EXPRESSION INVOLVEMENT CLEAVAGE VERSICAN RECEPTOR LIVER LINES RATS MICE Custom array EndoTox array Endotoxicity Mouse cell line Nonylphenol