Yoo, Ji-Hye Kang, Kyungsu Jho, Eun Hye Chin, Young-Won Kim, Jinwoong Nho, Chu Won 2024-01-20T15:34:48Z 2024-01-20T15:34:48Z 2021-09-05 2011-12-15 0308-8146 https://pubs.kist.re.kr/handle/201004/129713 Aberrant activation of Wnt/beta-catenin signalling via genetic errors within beta-catenin or APC has a crucial role in carcinogenesis. Here, we studied two xanthones, alpha- and gamma-mangostin, as inhibitors of Wnt/beta-catenin signalling. The mangostins inhibited TCF/beta-catenin transcriptional activity. The mangostins also inhibited protein expression of beta-catenin in colon cancer cells, but the inhibition was independent of the phosphorylation and degradation of beta-catenin. Instead, the mangostins increased the levels of cGMP and cGMP-dependent kinase, indicating that the inhibition of beta-catenin resulted from beta-catenin gene regulation. Our results indicate that mangostins could be potential candidates for preventing colon cancer through a novel mechanism of inhibiting Wnt/beta-catenin signalling. (C) 2011 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD COLORECTAL-CANCER GARCINIA-MANGOSTANA PROTEIN-KINASE WNT PATHWAY CYCLIC-GMP DERIVATIVES EXPRESSION PREVENTION XANTHONES MUTATIONS alpha- and gamma-Mangostin inhibit the proliferation of colon cancer cells via beta-catenin gene regulation in Wnt/cGMP signalling Article 10.1016/j.foodchem.2011.06.007 1 FOOD CHEMISTRY, v.129, no.4, pp.1559 - 1566 FOOD CHEMISTRY 129 4 1559 1566 scie scopus 000294979600032 2-s2.0-80051791437 Chemistry, Applied Food Science & Technology Nutrition & Dietetics Chemistry Food Science & Technology Nutrition & Dietetics Article COLORECTAL-CANCER GARCINIA-MANGOSTANA PROTEIN-KINASE WNT PATHWAY CYCLIC-GMP DERIVATIVES EXPRESSION PREVENTION XANTHONES MUTATIONS Mangostins beta-Catenin Transcriptional regulation cGMP PKG