Youn, Yong-Suk Oh, Jin Hee Ahn, Ki Ho Kim, Minsoo Kim, Jaehoon Lee, Youn-Woo 2024-01-20T16:02:20Z 2024-01-20T16:02:20Z 2021-09-05 2011-11 0896-8446 https://pubs.kist.re.kr/handle/201004/129832 In this study, the recrystallization of valsartan by ASES (Aerosol Solvent Extraction System), a supercritical micronization process, using compressed CO2 was carried out to improve the bioavailability of valsartan through preparation of micro sized particles without excessive agglomeration. Fine valsartan particles from an ethyl acetate (EA) solution were precipitated using compressed CO2 as an antisolvent at low temperature. The EA was considered a proper organic solvent to prevent agglomeration of the prepared valsartan associating to the solubility parameters of the solvents. Ultra fine valsartan particles with a mean diameter of 0.1 mu m were obtained without excessive agglomeration at the subcritical CO2 of 70 bar and 5 degrees C. When the supercritical CO2 was at 100 bar and 40 degrees C, valsartan was precipitated to fine particles that tended to agglomerated due to the melting point depression produced by CO2. During the agglomeration process, particles were sintered by the Ostwald ripening mechanism, which resulted in an increase in particle size. Agglomeration of the particles was shown to be prevented at low temperature, where remelting of the precipitated valsartan particles is minimized. Hence, processed valsartan with compressed CO2 at a low temperature improved its dissolution rate due to the small size of the particles attributing to low level of particle agglomeration. (C) 2011 Elsevier B.V. All rights reserved. English ELSEVIER SUPERCRITICAL ANTISOLVENT PRECIPITATION SOLID-LIQUID-GAS FINE PARTICLES CRYSTALLIZATION MICRONIZATION PARAMETERS MORPHOLOGY FLUIDS SIZE Dissolution rate improvement of valsartan by low temperature recrystallization in compressed CO2: Prevention of excessive agglomeration Article 10.1016/j.supflu.2011.07.008 1 JOURNAL OF SUPERCRITICAL FLUIDS, v.59, pp.117 - 123 JOURNAL OF SUPERCRITICAL FLUIDS 59 117 123 scie scopus 000296692100015 2-s2.0-80053575263 Chemistry, Physical Engineering, Chemical Chemistry Engineering Article SUPERCRITICAL ANTISOLVENT PRECIPITATION SOLID-LIQUID-GAS FINE PARTICLES CRYSTALLIZATION MICRONIZATION PARAMETERS MORPHOLOGY FLUIDS SIZE Valsartan Compressed CO2 ASES Dissolution rate Melting point depression Agglomeration Ostwald ripening