Ryu, Ju Hee Kim, Sun Ah Koo, Heebeom Yhee, Ji Young Lee, Aeju Na, Jin Hee Youn, Inchan Choi, Kuiwon Kwon, Ick Chan Kim, Byung-Soo Kim, Kwangmeyung 2024-01-20T16:02:28Z 2024-01-20T16:02:28Z 2021-09-05 2011-11 0959-9428 https://pubs.kist.re.kr/handle/201004/129839 We developed a cathepsin B-sensitive nanoprobe (CB-NP) with a cathepsin B substrate peptide probe and tumor-targeting glycol chitosan nanoparticles. The CB-NP could accumulate in tumor tissues, enter into tumor cells, and generate fluorescent signals in cytosol in response to cathepsin B. The results of non-invasive fluorescence imaging in a tumor-bearing mouse model demonstrated the potential of CB-NP for tumor diagnosis in clinical fields. English ROYAL SOC CHEMISTRY GLYCOL CHITOSAN NANOPARTICLES CANCER-THERAPY Cathepsin B-sensitive nanoprobe for in vivo tumor diagnosis Article 10.1039/c1jm13064a 1 JOURNAL OF MATERIALS CHEMISTRY, v.21, no.44, pp.17631 - 17634 JOURNAL OF MATERIALS CHEMISTRY 21 44 17631 17634 scie scopus 000296390600012 2-s2.0-80455163253 Chemistry, Physical Materials Science, Multidisciplinary Chemistry Materials Science Article GLYCOL CHITOSAN NANOPARTICLES CANCER-THERAPY