Yuk, Soon Hong Oh, Keun Sang Koo, Heebeom Jeon, Hyesung Kim, Kwangmeyung Kwon, Ick Chan 2024-01-20T16:02:30Z 2024-01-20T16:02:30Z 2021-09-05 2011-11 0142-9612 https://pubs.kist.re.kr/handle/201004/129840 The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology. (C) 2011 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD POLYETHYLENE-GLYCOL LIPOSOME FUSION LUNG-CANCER DOCETAXEL PACLITAXEL BILAYER INCREASES RELEASE Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs Article 10.1016/j.biomaterials.2011.07.017 1 BIOMATERIALS, v.32, no.31, pp.7924 - 7931 BIOMATERIALS 32 31 7924 7931 scie scopus 000295072600018 2-s2.0-80051817296 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Article POLYETHYLENE-GLYCOL LIPOSOME FUSION LUNG-CANCER DOCETAXEL PACLITAXEL BILAYER INCREASES RELEASE Drug delivery Multi-core vesicle nanoparticles Pluronic Docetaxel Chemotherapy