Yoon, Jeonghoon Cho, Jeiwon Kim, Namgon Kim, Dae-Duk Lee, Eunsook Cheon, Changyul Kwon, Youngwoo 2024-01-20T16:03:35Z 2024-01-20T16:03:35Z 2021-09-04 2011-10-15 0020-7136 https://pubs.kist.re.kr/handle/201004/129889 To overcome the limits of conventional microwave ablation, a new frequency spectrum above 6 GHz has been explored for low-power and low collateral damage ablation procedure. A planar coaxial probe-based applicator, suitable for easy insertion into the human body, was developed for our study to cover a wideband frequency up to 30 GHz. Thermal ablations with small input power (1-3 W) at various microwave frequencies were performed on nude mice xenografted with human breast cancer. Comparative study of ablation efficiencies revealed that 18-GHz microwave results in the largest difference in the temperature rise between cancer and normal tissues as well as the highest ablation efficiency, reaching 20 times that of 2 GHz. Thermal profile study on the composite region of cancer and fat also showed significantly reduced collateral damage using 18 GHz. Application of low-power (1 W) 18-GHz microwave on the nude mice xenografted with human breast cancer cells resulted in recurrence-free treatment. The proposed microwave ablation method can be a very effective process to treat small-sized tumor with minimized invasiveness and collateral damages. English WILEY DIELECTRIC-PROPERTIES PERMITTIVITY UNCERTAINTY CARCINOMA High-frequency microwave ablation method for enhanced cancer treatment with minimized collateral damage Article 10.1002/ijc.25845 1 INTERNATIONAL JOURNAL OF CANCER, v.129, no.8, pp.1970 - 1978 INTERNATIONAL JOURNAL OF CANCER 129 8 1970 1978 scie scopus 000294224300019 2-s2.0-80052038506 Oncology Oncology Article DIELECTRIC-PROPERTIES PERMITTIVITY UNCERTAINTY CARCINOMA microwave ablation breast cancer planar coaxial probe-based applicator collateral damage nude mouse xenograft model