Kim, Seong-Hwan Ko, Hyeonseok Bang, Hea-Son Park, Seon-Hui Kim, Dong-Gyu Kwon, Hak Cheol Kim, Sun Yeou Shin, Jongheon Oh, Dong-Chan 2024-01-20T16:03:58Z 2024-01-20T16:03:58Z 2021-09-05 2011-10-01 0960-894X https://pubs.kist.re.kr/handle/201004/129907 Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP+ (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells. (C) 2011 Elsevier Ltd. All rights reserved. English Pergamon Press Ltd. TYROSINE Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp. Article 10.1016/j.bmcl.2011.08.023 1 Bioorganic & Medicinal Chemistry Letters, v.21, no.19, pp.5715 - 5718 Bioorganic & Medicinal Chemistry Letters 21 19 5715 5718 scie scopus 000294714400010 2-s2.0-80052591205 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article TYROSINE Phenylpyridine Neuroprotective activity Dung beetle Copris tripartitus Streptomyces