Kang, Kyungsu Jho, Eun Hye Lee, Hee Ju Oidovsambuu, Sarangerel Yun, Ji Ho Kim, Chul Young Yoo, Ji-Hye Kim, Young-Jin Kim, Jong Hwan Ahn, Soo Young Nho, Chu Won 2024-01-20T16:04:34Z 2024-01-20T16:04:34Z 2021-09-05 2011-10 1096-620X https://pubs.kist.re.kr/handle/201004/129937 Improvement of liver function is one of the most popular commercial health claims of functional foods in Asian countries, including Korea. After examining the potential of several traditional Korean wild vegetables for enhancing liver function, we found that Youngia denticulata Kitam. has strong hepatoprotective effects against oxidative stress induced by tert-butylhydroperoxide (t-BHP). We are the first to report that the extract and ethyl acetate fractions of Y. denticulata have radical scavenging activities and inhibit oxidative stress induced cell death and DNA damage in HepG2 cells. The extract and ethyl acetate fractions significantly decreased cellular reactive oxygen species production and apoptosis induced by t-BHP in HepG2 cells. In addition, they prevented the depletion of cellular glutathione, which is an important defense molecule against oxidizing xenobiotics. Chlorogenic acid and 3,5-dicaffeoylquinic acid were found to be major active components responsible for the activity of E denticulata and could serve as marker compounds for standardization. These data suggest that Y. denticulata could be promoted as a potential antioxidative functional food candidate, particularly for hepatoprotection against oxidative stress. English MARY ANN LIEBERT INC BUTYL HYDROPEROXIDE HYDROGEN-PEROXIDE LIVER-DISEASES QUANTITATIVE-DETERMINATION CHLOROGENIC ACID HEPATOMA HEPG2 DNA-DAMAGE INDUCTION STRESS ASSAY Youngia denticulata Protects Against Oxidative Damage Induced by tert-Butylhydroperoxide in HepG2 Cells Article 10.1089/jmf.2010.1557 1 JOURNAL OF MEDICINAL FOOD, v.14, no.10, pp.1198 - 1207 JOURNAL OF MEDICINAL FOOD 14 10 1198 1207 scie scopus kci ART001601369 000295950000015 2-s2.0-80054087640 Chemistry, Medicinal Food Science & Technology Nutrition & Dietetics Pharmacology & Pharmacy Food Science & Technology Nutrition & Dietetics Article BUTYL HYDROPEROXIDE HYDROGEN-PEROXIDE LIVER-DISEASES QUANTITATIVE-DETERMINATION CHLOROGENIC ACID HEPATOMA HEPG2 DNA-DAMAGE INDUCTION STRESS ASSAY antioxidant apoptosis comet assay functional food hepatoprotection wild vegetable Youngia denticulata Kitam