Park, Hyun Bong Kim, Young-Joo Park, Jin-Soo Yang, Hyun Ok Lee, Kang Ro Kwon, Hak Cheol 2024-01-20T16:05:07Z 2024-01-20T16:05:07Z 2021-09-04 2011-10 0163-3864 https://pubs.kist.re.kr/handle/201004/129965 A new diketopiperazine, glionitrin B (1), was produced using a microbial coculture of the fungus Aspergillus fumigatus KMC-901 and the bacterium Sphingomonas sp. KMK-001 that were isolated from acidic coal mine drainage. The structure of 1 was determined to be (3S,10aS)-dithiomethylglionitrin A. This structure was determined by the analyses of extensive NMR data and the circular dichroism spectra of the natural product and a semisynthetic compound derived from glionitrin A. In contrast to glionitrin A (2), glionitrin B (1) is not cytotoxic against the human prostate cancer cell line DU145. However, compound 1 caused suppression of DU145 cell invasion, producing 46% inhibition at 60 mu M. English AMER CHEMICAL SOC ASPERGILLUS-FUMIGATUS GENE-CLUSTER BIOSYNTHESIS FUNGUS BISDETHIOBIS(METHYLTHIO)GLIOTOXIN IDENTIFICATION FERMENTATION ANTAGONISTS METABOLITE SCAFFOLD Glionitrin B, a Cancer Invasion Inhibitory Diketopiperazine Produced by Microbial Coculture Article 10.1021/np200563x 1 JOURNAL OF NATURAL PRODUCTS, v.74, no.10, pp.2309 - 2312 JOURNAL OF NATURAL PRODUCTS 74 10 2309 2312 scie scopus 000296206500045 2-s2.0-80055069175 Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Article ASPERGILLUS-FUMIGATUS GENE-CLUSTER BIOSYNTHESIS FUNGUS BISDETHIOBIS(METHYLTHIO)GLIOTOXIN IDENTIFICATION FERMENTATION ANTAGONISTS METABOLITE SCAFFOLD New Compound Microorganism Co-Culture Cancer Invasion Glionitrin B