Lee, Eun Ha Popov, S. A. Lee, Joo Young Shpatov, A. V. Kukina, T. P. Kang, Suk Woo Pan, Cheol Ho Um, Byung Hun Jung, Sang Hoon 2024-01-20T16:31:30Z 2024-01-20T16:31:30Z 2021-09-05 2011-09 1068-1620 https://pubs.kist.re.kr/handle/201004/130042 Aldose reductase (AR) is the first enzyme in the polyol pathway. AR has been reported to play an important role in the pathogenesis of diabetic complications. Ursolic acid and fourteen synthetic derivatives with ursane skeleton were tested for recombinant human aldose reductase (rhAR) inhibitory activity for development of diabetic complications. Among them, N-(3 beta-hydroxyurs-12-en-28-oyl)-4-aminobutyric acid (XV) showed most potent rhAR inhibitory activity in vitro. Inhibition mode of N-(3 beta-hydroxyurs-12-en-28-oyl)-4-aminobutyric acid (XV) was tested uncompetitively by kinetic analysis using the Lineweaver-Burk plots. Ursolic acid derivative N-(3 beta-hydroxyurs-12-en-28-oyl)-4-aminobutyric acid is able to inhibit rhAR uncompetitively and could be offered as a lead compound for AR inhibition. English MAIK NAUKA/INTERPERIODICA/SPRINGER DIABETIC COMPLICATIONS TRITERPENES SORBINIL Inhibitory effect of ursolic acid derivatives on recombinant human aldose reductase Article 10.1134/S1068162011050050 1 RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, v.37, no.5, pp.569 - 577 RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 37 5 569 577 scie scopus 000295533200007 2-s2.0-80055000521 Biochemistry & Molecular Biology Chemistry, Organic Biochemistry & Molecular Biology Chemistry Article DIABETIC COMPLICATIONS TRITERPENES SORBINIL aldose reductase N-(3 beta-hydroxyurs-12-en-28-oyl)-4-aminobutyric acid ursolic acid derivatives diabetic complications