Potta, Thrimoorthy Chun, ChangJu Song, Soo-Chang 2024-01-20T16:35:25Z 2024-01-20T16:35:25Z 2021-09-04 2011-07 0141-3910 https://pubs.kist.re.kr/handle/201004/130237 Thermosensitive and photo-cross-linkable poly(organophosphazenes) containing various amounts of isoleucine ethyl ester, AMPEG550, AMPEG750, aminoethyl methacrylate, and depsipeptide were synthesized, characterized, and were investigated for in vitro and in vivo degradation rates. The aqueous solutions of all polymers showed a sol-gel phase transition behavior against the temperature changes. The polymer degradation rate was majorly affected by the type and degree of the side group's substitutions. The rate of degradation was initially dependent on the degree of photo-cross-linking, and in later stages on the amounts of the depsipeptide and PEG chain lengths in the polymer network. The amount of the pendant depsipeptide and chain length of the alpha-amino-omega-methoxy-poly(ethylene glycol) had significant impact on the polymer degradation rates. The polymers with high amount of the depsipeptide, and PEG750 showed fast degradation. These results suggest that the degradation rate of the injectable and dual cross-linkable gels can be tuned to the desired extent and may find wide utilities in various biomedical applications, where the gel strength and degradation rate are needed to be tightly regulated. (C) 2011 Elsevier Ltd. All rights reserved. English ELSEVIER SCI LTD EXTRACELLULAR-MATRIX PLURONIC HYDROGEL CELL DELIVERY SCAFFOLDS SUBSTRATE STIFFNESS POLYMERS RELEASE GLYCOL) Controlling the degradation rate of thermoresponsive photo-cross-linked poly(organophosphazene) hydrogels with compositions of depsipeptide and PEG chain lengths Article 10.1016/j.polymdegradstab.2011.04.010 1 POLYMER DEGRADATION AND STABILITY, v.96, no.7, pp.1261 - 1270 POLYMER DEGRADATION AND STABILITY 96 7 1261 1270 scie scopus 000292410800013 2-s2.0-79957846023 Polymer Science Polymer Science Article EXTRACELLULAR-MATRIX PLURONIC HYDROGEL CELL DELIVERY SCAFFOLDS SUBSTRATE STIFFNESS POLYMERS RELEASE GLYCOL) Thermosensitive Photo-cross-linkable Poly(organophosphazene) Depsipeptide Degradation rate