Park, Hyun Bong Yang, Hyun Ok Lee, Kang Ro Kwon, Hak Cheol 2024-01-20T17:03:48Z 2024-01-20T17:03:48Z 2021-09-02 2011-05 1420-3049 https://pubs.kist.re.kr/handle/201004/130409 Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be alpha-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA. English MDPI ANTITUMOR-ANTIBIOTICS MARINE ACTINOMYCETE NATURAL-PRODUCTS A-D POLYKETIDE METABOLITES BIOSYNTHESIS RESISTANCE SPONGE Gombapyrones E and F, New alpha-Pyrone Polyenes Produced by Streptomyces sp. KMC-002 Article 10.3390/molecules16053519 1 MOLECULES, v.16, no.5, pp.3519 - 3529 MOLECULES 16 5 3519 3529 scie scopus 000290955800006 2-s2.0-79957616494 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article ANTITUMOR-ANTIBIOTICS MARINE ACTINOMYCETE NATURAL-PRODUCTS A-D POLYKETIDE METABOLITES BIOSYNTHESIS RESISTANCE SPONGE Streptomyces gombapyrone alpha-pyrone polyene