Ahn, Hyemi Lee, Jun A. Kim, Hwan Oh, Chang-Hyun Lee, So Ha Sim, Taebo Hah, Jung-Mi Kim, Dong Jin Yoo, Kyung Ho 2024-01-20T17:04:28Z 2024-01-20T17:04:28Z 2021-09-02 2011-04-20 0253-2964 https://pubs.kist.re.kr/handle/201004/130442 The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1e, 1h, and 1o showed superior antiproliferative activities to Sorafenib (IC(50) = 5.5 mu M) as a reference compound. In our series, urea compound 1o having 4-chloro-3-trifluoromethyl moiety on the benzene nucleus exhibited very good antiproliferative activity with IC(50) value of 1.4 mu M. English KOREAN CHEMICAL SOC RANDOMIZED PHASE-III METASTATIC MELANOMA MALIGNANT-MELANOMA DACARBAZINE CHEMOTHERAPY CISPLATIN DERIVATIVES TARGETS Synthesis and Antiproliferative Activity of Pyridinylcarbonylpyrimidines Against Melanoma Cell Line Article 10.5012/bkcs.2011.32.4.1209 1 BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.32, no.4, pp.1209 - 1214 BULLETIN OF THE KOREAN CHEMICAL SOCIETY 32 4 1209 1214 scie scopus kci ART001545202 000290366200020 2-s2.0-79954609530 Chemistry, Multidisciplinary Chemistry Article RANDOMIZED PHASE-III METASTATIC MELANOMA MALIGNANT-MELANOMA DACARBAZINE CHEMOTHERAPY CISPLATIN DERIVATIVES TARGETS Pyridinylcarbonylpyrimidines Antiproliferative activity Melanoma cell line