Xie, Jin Zhang, Fan Aronova, Maria Zhu, Lei Lin, Xin Quan, Qimeng Liu, Gang Zhang, Guofeng Choi, Ki-Young Kim, Kwangmeyung Sun, Xiaolian Lee, Seulki Sun, Shouheng Leapman, Richard Chen, Xiaoyuan 2024-01-20T17:05:18Z 2024-01-20T17:05:18Z 2021-09-02 2011-04 1936-0851 https://pubs.kist.re.kr/handle/201004/130483 We and others have recently proposed the synthesis of composite nanoparticles that offer strongly enhanced functionality. Here we have used a flower-shaped Au-Fe3O4 nanoparticle as a template to construct an optical probe containing Cy5.5-GPLGVRG-TDOPA on the iron oxide surface and SH-PEG(5000) on the gold surface, that can be specifically activated by matrix metalloproteinases expressed in tumors. Gold nanoparticles have excellent quenching properties, but labile surface chemistry in vivo; on the other hand, iron oxide nanoparticles afford robust surface chemistry, but are suboptimal as energy receptors. By a marriage of the two, we have produced a unified structure with performance that Is unachievable with the separate components. Our results are a further demonstration that the architecture of nanoparticles can be modulated to tailor their function as molecular imaging/therapeutic agents. English AMER CHEMICAL SOC IRON-OXIDE NANOPARTICLES GOLD NANOPARTICLES MAGNETIC NANOPARTICLES HETEROSTRUCTURED NANOPARTICLES FUNCTIONAL MOLECULES PROBES DELIVERY Manipulating the Power of an Additional Phase: A Flower-like Au-Fe3O4 Optical Nanosensor for Imaging Protease Expressions In vivo Article 10.1021/nn200161v 1 ACS NANO, v.5, no.4, pp.3043 - 3051 ACS NANO 5 4 3043 3051 scie scopus 000289742100073 2-s2.0-79955430587 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article IRON-OXIDE NANOPARTICLES GOLD NANOPARTICLES MAGNETIC NANOPARTICLES HETEROSTRUCTURED NANOPARTICLES FUNCTIONAL MOLECULES PROBES DELIVERY composite nanoparticles Au-Fe3O4 matrix metalloproteinase activatable probes near-infrared fluorescence imaging